ABSTRACT
1. The role of testosterone (T) in growth was evaluated in 11 prepubertal hypopituitary males during two 15-day periods separated by a 4-week interval, i.e., before (PRE-T period) and during T ester treatment (50 mg every 5 days, 3 im doses-T period). 2. T increased growth hormone (GH) secretion, assessed by 4-h rhythm (mean +/- SEM = 1.90 +/- 0.27 vs 1.77 +/- 0.21 ng/ml; P < 0.05) and after a GHRH stimulus (3.42 +/- 0.54 vs 3.08 +/- 0.43 ng/ml; P < 0.05) as compared to the PRE-T period. 3. T also increased basal somatomedin-C (SM-C) levels (0.20 +/- 0.03 vs 0.15 +/- 0.02 U/ml; P < 0.001) and SM-C generation. After GH was administered in 4 im doses (0.01, 0.02, 0.05 and 0.1 U/kg), SM-C levels were 0.31 +/- 0.08 vs 0.24 +/- 0.07 U/ml, P < 0.001. T did not change incremental (absolute minus basal) SM-C levels (0.15 +/- 0.08 vs 0.12 +/- 0.07 U/ml; P > 0.05). 4. The results suggest that T increased plasma SM-C levels by stimulating residual GH secretion in hypopituitary males
Subject(s)
Humans , Male , Insulin-Like Growth Factor I/drug effects , Puberty/drug effects , Growth Hormone/deficiency , Growth Hormone/drug effects , Growth Hormone , Testosterone/therapeutic use , Adolescent , Adult , Analysis of Variance , Child , Hypopituitarism/blood , Hypopituitarism/drug therapy , Hypopituitarism/epidemiology , Insulin-Like Growth Factor I/analysis , Puberty/blood , Growth Hormone/blood , Time FactorsABSTRACT
Sao analisados tres pacientes que apresentaram comprometimento da funcao respiratoria apos acidente por Crotalus durissus. As manifestacoes respiratorias surgiram nas primeiras 48 horas apos a picada do ofidio e consistiram de dispneia, taquipneia, uso da musculatura acessoria da respiracao (casos 1 e 2) e batimento das aletas nasais (caso 2). Dois pacientes (casos 1 e 2) apresentaram insuficiencia respiratoria aguda. O diagnostico desta complicacao no caso 1 foi clinico pois o paciente apresentou apneia. O paciente do caso 2, 24 horas apos o acidente ofidico apresentou dificuldade respiratoria intensa e periodos de apneia sendo intubado, permanecendo em respiracao espontanea. Houve agravamento dos sinais clinicos de insuficiencia respiratoria e a determinacao de pH e gases do sangue arterial mostrou em relacao ao exame inicial elevacao da pressao parcial de gas carbonico (40 mmHg para 50,3 mmHg) caracterizando insuficiencia ventilatoria aguda. Ambos foram tratados com emprego de ventilacao artificial mecanica, tendo o paciente do caso 1 permanecido no ventilador durante 33 dias e o do caso 2 durante 15 dias. Ambos desenvolveram insuficiencia renal aguda, necessitaram de dialise peritoneal e recuperaram a funcao renal. A paciente do caso 3, apesar dos sintomas e sinais de comprometimento respiratorio...